| Player | Team | Goals | Assists | Matches | |
|---|---|---|---|---|---|
| 1 | C. Benteke | DC United | 23 | 5 | 30 |
| 2 | L. Suárez | Inter Miami | 21 | 9 | 30 |
| 3 | L. Messi | Inter Miami | 21 | 11 | 22 |
| 4 | D. Joveljić | Los Angeles Galaxy | 21 | 5 | 33 |
| 5 | D. Bouanga | Los Angeles FC | 21 | 7 | 36 |
| 6 | Gabriel Pec | Los Angeles Galaxy | 19 | 14 | 38 |
| 7 | C. Hernández | Columbus Crew | 19 | 8 | 29 |
| 8 | A. Martínez | New York City FC | 17 | 3 | 30 |
| 9 | Riqui Puig | Los Angeles Galaxy | 17 | 12 | 33 |
| 10 | C. Arango | Real Salt Lake | 17 | 6 | 32 |
| 11 | D. Gazdag | Philadelphia Union | 17 | 2 | 30 |
| 12 | M. Bogusz | Los Angeles FC | 16 | 7 | 36 |
| 13 | B. White | Vancouver Whitecaps | 16 | 2 | 34 |
| 14 | J. Rodríguez | Portland Timbers | 16 | 4 | 30 |
| 15 | P. Musa | FC Dallas | 16 | 3 | 30 |
| 16 | F. Torres | Orlando City SC | 16 | 3 | 37 |
| 17 | Evander | Portland Timbers | 15 | 13 | 29 |
| 18 | R. Gauld | Vancouver Whitecaps | 15 | 12 | 34 |
| 19 | Rafael Navarro | Colorado Rapids | 15 | 1 | 36 |
| 20 | J. Morris | Seattle Sounders | 14 | 4 | 37 |